Hypophrenia means a feeling of sadness for no apparent reason, what it describes are the moments in which we should be happy, but for some reason that we do not understand we feel sadness. The painting is made with inspiration from Renaissance works, with its characteristic realism and detail. It is a work that reflects the complexity of human emotions, which sometimes do not correspond to external reality. It is a work that invites us to reflect on our state of mind, on the causes and consequences of hypophrenia.